Near-Infrared Light for Neuroblastoma Cells

Effects of Pulsed Red and Near-Infrared Light on Neuroblastoma Cells—Pilot Study on Frequency and Duty Cycle

Lumaflex Research Institute

Study Overview

Description:  An in vitro pilot study to determine how pulsed light (PW) with different frequencies and duty cycles compares to continuous light (CW) in affecting neuroblastoma cell metabolism.

Source: Mdpi

Summary

Focus: SH-SY5Y neuroblastoma cells (in vitro).

Intervention: Exposure to 660 nm red and 850 nm near-infrared light, both pulsed (at 40 Hz, 100 Hz, 1000 Hz with varying duty cycles) and continuous wave.

Methods:  Measurement of ATP, mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and cell viability.

Conclusion

Pulsed light at 40 Hz with a 10% duty cycle showed the strongest positive response in enhancing mitochondrial function and cell viability in neuroblastoma cells.