660-Effect of Photobiomodulation Therapy Associated With Biphasic Phosphate Calcium on Bone Repair
Study Overview
- Description: This study investigated the effects of Photobiomodulation (PBM) therapy combined with biphasic calcium phosphate on critical calvaria defects in rats.
- Source: PubMed
Summary
- Participants: 48 adult male Wistar rats, each with a 5 mm critical calvarial defect.
- Groups: Randomized into four groups: C (blood clot), B (biphasic calcium phosphate), L (PBM therapy), and B+L (biphasic calcium phosphate + PBM therapy).
- Results:At 60 days, Group L (PBM alone) showed a statistically significant difference when comparing the remaining distance between the edges of neoformed bone to all other groups (C, B, and B+L), demonstrating a greater defect closure.A statistically significant difference was found between the proportion of neoformation area in Group L (0.52%±0.13) and Group B+L (0.20%±0.08).
- At 60 days, Group L (PBM alone) showed a statistically significant difference when comparing the remaining distance between the edges of neoformed bone to all other groups (C, B, and B+L), demonstrating a greater defect closure.
- A statistically significant difference was found between the proportion of neoformation area in Group L (0.52%±0.13) and Group B+L (0.20%±0.08).
- Conclusion: The findings suggest that while biphasic calcium phosphate exerts some osteogenic activity during bone repair, PBM therapy was not able to modulate (or enhance) this process when combined. PBM therapy alone demonstrated better results in defect closure.
