Accelerated Bone Healing with 660 nm Low-Level Laser Therapy and Bone Marrow Coagulation

Study Overview

• Description: This study evaluated the effects of bone marrow aspirate (BMA) and low-level laser therapy (LLLT) on bone healing. Critical-size defects were created in rat calvaria and divided into four groups to observe bone healing under different treatment protocols.
• Source: PubMed

Summary

• Participants: 64 rats, in whose calvaria 5 mm diameter critical-size defects were created.
• Intervention: The rats were randomly divided into four groups:
• Control: Treated with a blood clot only.
• BMA: Treated with coagulated bone marrow aspirate.
• LLLT: Treated with laser irradiation and a blood clot.
• BMA/LLLT: Treated with laser irradiation and coagulated bone marrow aspirate.
• Methods: The rats were euthanized at 15 or 30 days postoperative to evaluate bone healing.
• Conclusion: This study demonstrated that bone marrow coagulated and low-level laser therapy accelerate bone healing by enhancing angiogenesis, cell proliferation, osteoblast differentiation, and mineralization.