1064 Potential effects of photobiomodulation therapy on wound healing in diabetic patients: A systematic review

Study: Potential effects of photobiomodulation therapy on wound healing in diabetic patients: A systematic review

Study Overview

• Description: This article reviews the potential role of Photobiomodulation Therapy (PBMT) in accelerating and improving wound healing in patients with diabetes, focusing on its mechanism of action at the molecular and cellular levels.
• Source: PubMed 

Summary

• Background: The healing of diabetic wounds, such as diabetic foot ulcers, is a complex challenge, often delayed or impaired due to sustained inflammation, infection, poor circulation, and cellular dysfunction. PBMT (often referred to as LLLT) is a promising adjunctive therapy due to its non-invasiveness, low cost, and pleiotropic effects.
• Challenges in Diabetic Wound Healing:Sustained Inflammation: Prolonged inflammatory phase hinders progression to the proliferative phase.Angiogenesis Defect: Impaired ability to form new blood vessels.Impaired Cell Proliferation and Migration: Poor function of fibroblasts and keratinocytes.
• Sustained Inflammation: Prolonged inflammatory phase hinders progression to the proliferative phase.
• Angiogenesis Defect: Impaired ability to form new blood vessels.
• Impaired Cell Proliferation and Migration: Poor function of fibroblasts and keratinocytes.
• Mechanism of Action of PBMT: PBMT, by localized light application, helps overcome the barriers to diabetic wound healing at the cellular level. Its effects include:Modulating Inflammation: Reducing excessive and sustained inflammation.Enhancing Cell Viability and Proliferation: Promoting the growth and migration of fibroblasts and keratinocytes, thus facilitating wound closure.Stimulating Angiogenesis: Improving blood supply to the wound site.Increasing Collagen Synthesis: Promoting collagen deposition and wound remodeling.
• Modulating Inflammation: Reducing excessive and sustained inflammation.
• Enhancing Cell Viability and Proliferation: Promoting the growth and migration of fibroblasts and keratinocytes, thus facilitating wound closure.
• Stimulating Angiogenesis: Improving blood supply to the wound site.
• Increasing Collagen Synthesis: Promoting collagen deposition and wound remodeling.
• Conclusion: Although PBMT has shown significant benefits in animal models and some clinical studies, more rigorously designed randomized controlled clinical trials are still needed to determine the optimal treatment parameters (e.g., wavelength, energy density, frequency) and standardize treatment protocols to fully realize the immense potential of PBMT in improving diabetic wound healing.