Laser Photobiomodulation 904 nm Promotes Inhibition of Hormone-Sensitive Lipase Activity in 3T3-L1 Differentiated Cells

Study Overview

• Description: This study analyzed the effects of 904 nm laser photobiomodulation (PBM) on the activity of hormone-sensitive lipase (HSL), a key enzyme in the hydrolysis of triglycerides in adipose tissue.
• Source: PubMed 

Summary

• Participants: 3T3-L1 differentiated adipocytes.
• Intervention: Cells were differentiated into adipocytes, irradiated with a 904 nm laser at doses of 1, 2, and 3 Joules, and incubated for 4 hours post-irradiation.
• Methods: HSL activity and triglyceride levels in the medium were analyzed.
• Conclusion: 904 nm laser photobiomodulation was able to inhibit HSL activity (with statistically significant differences compared to the control group). However, no modulation was observed in triglyceride levels in the medium. This is the first study to show HSL activity modulation with laser radiation, suggesting that photobiomodulation can influence adipose tissue metabolism and opens a new field of study.